How to remove all the interactions from a prototype?

Hi Everyone, is there a way to remove all interactions in one go?

If you choose Prototype > Remove All Links from [pagename] that should do it for you, on that one Page specifically (not just the Artboard, but the entire Page).
Note that you might still see some Prototyping wires showing on this page if they are contained within Symbols, so you would need to do the same action on the Symbols page too.